CASTLE-AF
Catheter Ablation versus Standard Conventional Therapy in Patients with LV Dysfunction and AF
Paciente / Población Intervención / Exposición Comparación Desenlace
In 363 patients with AF and heart failure with reduced ejection fraction, catheter ablation reduced death or heart-failure hospitalisation compared with medical therapy.
N
363
Diseño
Open-label RCT
Desenlace
Death or HF hospitalisation
Relevancia
2
Resultado28.5 % vs 44.6 % (HR 0.62); all-cause mortality HR 0.53.
Marrouche NF, et al. N Engl J Med. 2018;378(5):417-427. 10.1056/NEJMoa1707855
Discusión y crítica
Highly selected patients at experienced centres over a long enrolment period. Still the basis for a class I recommendation for ablation in AF with HFrEF.