BOX (O₂)
Oxygen Targets after Out-of-Hospital Cardiac Arrest
Paciente / Población Intervención / Exposición Comparación Desenlace
In 789 comatose survivors of OHCA, restrictive oxygenation (PaO₂ 68–75 mm Hg) did not change the composite of death or severe disability compared with liberal (98–105 mm Hg).
N
789
Diseño
Multicentre factorial RCT (BOX), Denmark
Desenlace
Death or severe disability/coma at 90 days
Relevancia
3
Resultado32% vs 34% (HR 0.95).
Schmidt H, et al. N Engl J Med. 2022;387(16):1467-1476. 10.1056/NEJMoa2208686
Discusión y crítica
Target normoxia (SpO₂ 94–98%); avoid hyperoxia without chasing tight low-end targets.