ATN
VA/NIH Acute Renal Failure Trial Network Study
Patient / Population Intervention / Exposure Comparison Outcome
In 1,124 critically ill patients with acute kidney injury, intensive renal-replacement therapy did not reduce mortality compared with less-intensive therapy.
N
1,124
Design
RCT
Endpoint
60-day all-cause mortality
Relevance
2
Result53.6% vs 51.5%; OR 1.09 (95% CI 0.86–1.40; p=0.47).
VA/NIH Acute Renal Failure Trial Network. N Engl J Med. 2008;359(1):7-20. 10.1056/NEJMoa0802639
Discussion & critique
A higher dialysis dose gave no survival benefit in AKI.