AKIKI
Artificial Kidney Initiation in Kidney Injury
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 620 critically ill patients with stage 3 AKI, an early renal-replacement strategy did not improve survival compared with a delayed strategy.
N
620
Design
Multicentre RCT
Endpunkt
60-day mortality
Relevanz
2
Ergebnis48.5% vs 49.7%; no difference; about half of the delayed arm avoided dialysis altogether.
Gaudry S, et al. N Engl J Med. 2016;375(2):122-133. 10.1056/NEJMoa1603017
Diskussion & Kritik
Countered ELAIN; many patients never need dialysis if clinicians wait.