AFFIRM
Atrial Fibrillation Follow-up Investigation of Rhythm Management
Doente / População Intervenção / Exposição Comparação Desfecho
In 4,060 patients with AF at high risk of stroke, a rhythm-control strategy did not reduce all-cause mortality compared with rate control.
N
4060
Desenho
RCT, mean 3.5 yr
Desfecho
All-cause mortality
Relevância
2
Resultado23.8% vs 21.3% (HR 1.15, 95% CI 0.99–1.34, P=0.08). Trend favouring rate control.
AFFIRM Investigators. N Engl J Med. 2002;347(23):1825-1833. 10.1056/NEJMoa021328
Discussão e crítica
Era of class IC/III drugs, no ablation arm. EAST-AFNET 4 (2020) re-opened the question for early AF with modern strategies.