2025BPROADBP targetIn 12,821 patients with type 2 diabetes, intensive blood-pressure control to below 120 mm Hg reduced major cardiovascular events compared with a target below 140 mm Hg.
2023SPYRAL HTN-ON MEDRenal denervationIn 337 patients with uncontrolled hypertension on 1-3 antihypertensive drugs, radiofrequency renal denervation did not significantly lower 24-hour ambulatory systolic blood pressure at 6 months versus a sham procedure (-1.9 mmHg, 95% CI -4.4 to 0.5).
2022CHAPHypertension in pregnancyIn 2,408 pregnant women with mild chronic hypertension, antihypertensive treatment targeting a blood pressure below 140/90 mmHg reduced severe pre-eclampsia, medically indicated preterm birth, placental abruption or fetal or neonatal death compared with treatment withheld unless blood pressure reached 160/105 mmHg.
2017ASPREPre-eclampsia preventionIn 1,776 women with singleton pregnancies at high risk of preterm pre-eclampsia on first-trimester screening, aspirin 150 mg daily from 11–14 until 36 weeks reduced delivery with pre-eclampsia before 37 weeks compared with placebo.
2015SPRINTBP targetIn 9,361 high-risk non-diabetic hypertensive adults, intensive BP control to SBP < 120 mm Hg reduced CV events and all-cause mortality compared with standard control to SBP < 140 mm Hg.
2015CHIPSHypertension in pregnancyIn 987 pregnant women with non-proteinuric pre-existing or gestational hypertension, less-tight blood-pressure control did not reduce pregnancy loss or high-level neonatal care compared with tight control targeting a diastolic pressure of 85 mmHg, but led to far more severe maternal hypertension.
2015PATHWAY-2MRAIn 335 patients with drug-resistant hypertension, add-on spironolactone lowered home systolic blood pressure more than placebo, bisoprolol, or doxazosin.
2014SYMPLICITY HTN-3Renal denervationIn 535 patients with resistant hypertension, catheter-based renal denervation did not lower office systolic blood pressure compared with a sham procedure.
2008ACCOMPLISHDrug classIn 11,506 high-risk patients with hypertension, an ACE inhibitor plus amlodipine reduced cardiovascular events compared with an ACE inhibitor plus hydrochlorothiazide.
2008HYVETElderlyIn 3,845 patients with hypertension aged 80 or older, antihypertensive treatment reduced stroke and all-cause mortality compared with placebo.
2002ALLHATDrug classIn 33,357 hypertensive patients ≥ 55 with ≥ 1 CV risk factor, chlorthalidone was at least as effective as amlodipine or lisinopril for preventing fatal CHD or non-fatal MI.
2002MAGPIEEclampsia preventionIn 10,141 women with pre-eclampsia before delivery or shortly afterwards, magnesium sulphate halved the risk of eclamptic convulsions compared with placebo, without reducing perinatal death.