Yahav 2019
Seven vs Fourteen Days of Antibiotics for Gram-Negative Bacteraemia
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 604 patients with uncomplicated Gram-negative bacteraemia, 7 days of antibiotic therapy was non-inferior to 14 days for a composite of clinical failure, relapse and death at 90 days.
N
604
Disegno
Open-label non-inferiority RCT
Esito
Composite clinical failure / relapse / death
Rilevanza
2
Risultato45.8 % vs 48.3 % — non-inferior; faster return to baseline activity with 7 days.
Yahav D, et al. Clin Infect Dis. 2019;69(7):1091-1098. 10.1093/cid/ciy1054
Discussione e critica
Established 7 days as default for uncomplicated GN bacteraemia — predominantly urinary and Enterobacterales — paving the way for BALANCE.