van Nood FMT
Duodenal Infusion of Donor Faeces for Recurrent Clostridium difficile
Doente / População Intervenção / Exposição Comparação Desfecho
In 43 patients with recurrent Clostridium difficile infection, faecal microbiota transplantation achieved cure more often than oral vancomycin.
N
43
Desenho
RCT, stopped early for striking efficacy
Desfecho
Cure without relapse at 10 weeks
Relevância
3
Resultado~94 % vs ~31 % — overwhelming superiority of FMT.
van Nood E, et al. N Engl J Med. 2013;368(5):407-415. 10.1056/NEJMoa1205037
Discussão e crítica
First randomised proof of FMT efficacy in recurrent CDI — directly led to today's live-biotherapeutic products and the FMT standard of care.