van Nood FMT
Duodenal Infusion of Donor Faeces for Recurrent Clostridium difficile
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 43 patients with recurrent Clostridium difficile infection, faecal microbiota transplantation achieved cure more often than oral vancomycin.
N
43
Design
RCT, stopped early for striking efficacy
Endpunkt
Cure without relapse at 10 weeks
Relevanz
3
Ergebnis~94 % vs ~31 % — overwhelming superiority of FMT.
van Nood E, et al. N Engl J Med. 2013;368(5):407-415. 10.1056/NEJMoa1205037
Diskussion & Kritik
First randomised proof of FMT efficacy in recurrent CDI — directly led to today's live-biotherapeutic products and the FMT standard of care.