UKPDS 34
UK Prospective Diabetes Study 34
Doente / População Intervenção / Exposição Comparação Desfecho
In 753 overweight patients with newly diagnosed type 2 diabetes, intensive control with metformin reduced diabetes-related endpoints and all-cause mortality compared with conventional therapy.
N
753
Desenho
RCT, median 10.7 yr follow-up
Desfecho
Any diabetes-related endpoint
Relevância
1
ResultadoAny diabetes endpoint −32 % (p=0.002); all-cause mortality −36 % (p=0.011); MI −39 % (p=0.01).
UKPDS Group. Lancet. 1998;352(9131):854-865. 10.1016/S0140-6736(98)07037-8
Discussão e crítica
Established metformin as first-line therapy in overweight T2DM — a position it still holds.