Glycaemic control in diabetes
4 trials- 2008ACCORDIntensive vs standard glycaemiaIn 10,251 patients with long-standing T2DM and CV disease or risk factors, intensive glucose control targeting HbA1c <6.0 % increased all-cause mortality compared with standard control (7.0–7.9 %).
- 2008ADVANCEIntensive vs standard glycaemiaIn 11,140 patients with T2DM at high CV risk, gliclazide-based intensive control to HbA1c ≤6.5 % reduced the composite of microvascular and macrovascular events versus standard care.
- 1998UKPDS 33Intensive glycaemic controlIn 3,867 patients with newly diagnosed type 2 diabetes, intensive glucose control with sulfonylurea or insulin reduced microvascular endpoints compared with conventional diet-based therapy.
- 1998UKPDS 34MetforminIn 753 overweight patients with newly diagnosed type 2 diabetes, intensive control with metformin reduced diabetes-related endpoints and all-cause mortality compared with conventional therapy.