UKPDS 34

UK Prospective Diabetes Study 34

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 753 overweight patients with newly diagnosed type 2 diabetes, intensive control with metformin reduced diabetes-related endpoints and all-cause mortality compared with conventional therapy.

753

Disegno

RCT, median 10.7 yr follow-up

Esito

Any diabetes-related endpoint

Rilevanza

RisultatoAny diabetes endpoint −32 % (p=0.002); all-cause mortality −36 % (p=0.011); MI −39 % (p=0.01).

UKPDS Group. Lancet. 1998;352(9131):854-865. 10.1016/S0140-6736(98)07037-8

Discussione e critica

Established metformin as first-line therapy in overweight T2DM — a position it still holds.