UKPDS 33

UK Prospective Diabetes Study 33

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 3,867 patients with newly diagnosed type 2 diabetes, intensive glucose control with sulfonylurea or insulin reduced microvascular endpoints compared with conventional diet-based therapy.

3867

Disegno

RCT, median 10 yr follow-up

Esito

Combined diabetes-related endpoints

Rilevanza

RisultatoHbA1c 7.0 % vs 7.9 %. Microvascular endpoints −25 % (p=0.01); macrovascular endpoints not significantly reduced.

UKPDS Group. Lancet. 1998;352(9131):837-853. 10.1016/S0140-6736(98)07019-6

Discussione e critica

Established the strategy of early glucose-lowering and the HbA1c target. The legacy effect was confirmed in the 10-year follow-up (UKPDS 80).