UKPDS 33
UK Prospective Diabetes Study 33
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 3,867 patients with newly diagnosed type 2 diabetes, intensive glucose control with sulfonylurea or insulin reduced microvascular endpoints compared with conventional diet-based therapy.
N
3.867
Design
RCT, median 10 yr follow-up
Endpunkt
Combined diabetes-related endpoints
Relevanz
1
ErgebnisHbA1c 7.0 % vs 7.9 %. Microvascular endpoints −25 % (p=0.01); macrovascular endpoints not significantly reduced.
UKPDS Group. Lancet. 1998;352(9131):837-853. 10.1016/S0140-6736(98)07019-6
Diskussion & Kritik
Established the strategy of early glucose-lowering and the HbA1c target. The legacy effect was confirmed in the 10-year follow-up (UKPDS 80).