TARGET
Energy-Dense versus Standard Enteral Nutrition
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 3,957 mechanically ventilated ICU patients, energy-dense formula (1.5 kcal/mL) did not change 90-day mortality versus standard (1.0 kcal/mL).
N
3957
Disegno
Multicentre double-blind RCT, ANZ
Esito
90-day all-cause mortality
Rilevanza
2
Risultato26.8% vs 25.7% (RR 1.05; p=0.41).
TARGET Investigators. N Engl J Med. 2018;379(19):1823-1834. 10.1056/NEJMoa1811687
Discussione e critica
More calories isn't better; ESPEN/ASPEN endorse hypocaloric early feeding.