TARGET
Energy-Dense versus Standard Enteral Nutrition
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 3,957 mechanically ventilated ICU patients, energy-dense formula (1.5 kcal/mL) did not change 90-day mortality versus standard (1.0 kcal/mL).
N
3 957
Schéma
Multicentre double-blind RCT, ANZ
Critère
90-day all-cause mortality
Pertinence
2
Résultat26.8% vs 25.7% (RR 1.05; p=0.41).
TARGET Investigators. N Engl J Med. 2018;379(19):1823-1834. 10.1056/NEJMoa1811687
Discussion et critique
More calories isn't better; ESPEN/ASPEN endorse hypocaloric early feeding.