SYMPLICITY HTN-3
Renal Denervation in Patients with Resistant Hypertension
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 535 patients with resistant hypertension, catheter-based renal denervation did not lower office systolic blood pressure compared with a sham procedure.
N
535
Disegno
Sham-controlled, blinded RCT
Esito
Change in office systolic BP at 6 months
Rilevanza
3
RisultatoNo significant difference versus sham.
Bhatt DL, et al. N Engl J Med. 2014;370(15):1393-1401. 10.1056/NEJMoa1402670
Discussione e critica
The first sham-controlled denervation trial — its neutral result forced the field to rebuild with better technique. Later sham-controlled trials (SPYRAL, RADIANCE) were positive.