SYMPLICITY HTN-3
Renal Denervation in Patients with Resistant Hypertension
Paciente / Población Intervención / Exposición Comparación Desenlace
In 535 patients with resistant hypertension, catheter-based renal denervation did not lower office systolic blood pressure compared with a sham procedure.
N
535
Diseño
Sham-controlled, blinded RCT
Desenlace
Change in office systolic BP at 6 months
Relevancia
3
ResultadoNo significant difference versus sham.
Bhatt DL, et al. N Engl J Med. 2014;370(15):1393-1401. 10.1056/NEJMoa1402670
Discusión y crítica
The first sham-controlled denervation trial — its neutral result forced the field to rebuild with better technique. Later sham-controlled trials (SPYRAL, RADIANCE) were positive.