STICH
Surgical Treatment for Ischemic Heart Failure — Extension Study (STICHES, 10-year follow-up)
Doente / População Intervenção / Exposição Comparação Desfecho
In 1,212 patients with ischaemic cardiomyopathy (EF ≤ 35%) and CAD, coronary-artery bypass grafting plus medical therapy reduced 10-year all-cause mortality compared with medical therapy alone.
N
1212
Desenho
Open-label RCT with extended follow-up
Desfecho
All-cause mortality
Relevância
2
ResultadoAt 10 years, 58.9% died with CABG plus medical therapy vs 66.1% with medical therapy alone (HR 0.84, 95% CI 0.73-0.97; P=0.02); CV death and death-or-CV-hospitalisation also reduced.
Velazquez EJ, et al. N Engl J Med. 2016;374(16):1511-1520. 10.1056/NEJMoa1602001
Discussão e crítica
Original 5-year STICH result was neutral for the primary endpoint; significant survival benefit emerged only with 10-year follow-up, with substantial crossover between arms. Established a durable survival benefit of CABG in ischaemic cardiomyopathy.