SPICE-III
Early Sedation with Dexmedetomidine in Critical Illness
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 4,000 mechanically ventilated ICU patients, early dexmedetomidine did not change 90-day mortality versus usual sedation, with more bradycardia and hypotension.
N
4.000
Design
Multicentre RCT, 8 countries
Endpunkt
90-day all-cause mortality
Relevanz
2
Ergebnis29.1% vs 29.1% (Δ 0.0; 95% CI −2.9 to 2.8). Bradycardia 5.1% vs 0.5%. Age-dependent effect.
Shehabi Y, et al. N Engl J Med. 2019;380(26):2506-2517. 10.1056/NEJMoa1904710
Diskussion & Kritik
Dexmedetomidine is one tool among several; it's not a universal default and has age-dependent effects.