SOAP II
Comparison of Dopamine and Norepinephrine in the Treatment of Shock
Doente / População Intervenção / Exposição Comparação Desfecho
In 1,679 patients with shock, noradrenaline produced similar mortality but fewer arrhythmias compared with dopamine.
N
1679
Desenho
Double-blind RCT
Desfecho
28-day mortality
Relevância
2
ResultadoMortality similar; more arrhythmic events with dopamine; dopamine worse in the cardiogenic-shock subgroup.
De Backer D, et al. N Engl J Med. 2010;362(9):779-789. 10.1056/NEJMoa0907118
Discussão e crítica
Made noradrenaline the default vasopressor in shock and effectively retired dopamine, especially in cardiogenic shock.