SOAP II
Comparison of Dopamine and Norepinephrine in the Treatment of Shock
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 1,679 patients with shock, noradrenaline produced similar mortality but fewer arrhythmias compared with dopamine.
N
1 679
Schéma
Double-blind RCT
Critère
28-day mortality
Pertinence
2
RésultatMortality similar; more arrhythmic events with dopamine; dopamine worse in the cardiogenic-shock subgroup.
De Backer D, et al. N Engl J Med. 2010;362(9):779-789. 10.1056/NEJMoa0907118
Discussion et critique
Made noradrenaline the default vasopressor in shock and effectively retired dopamine, especially in cardiogenic shock.