SMART
Isotonic Solutions and Major Adverse Renal Events Trial
Paciente / Población Intervención / Exposición Comparación Desenlace
In 15,802 ICU patients, balanced crystalloids reduced the composite of major adverse kidney events at 30 days versus saline.
N
15.802
Diseño
Cluster-randomised crossover trial, Vanderbilt
Desenlace
MAKE30 (death, RRT or persistent renal dysfunction)
Relevancia
2
Resultado14.3% vs 15.4% (OR 0.91; p=0.04).
Semler MW, et al. N Engl J Med. 2018;378(9):829-839. 10.1056/NEJMoa1711584
Discusión y crítica
Small absolute effect but a defensible default for balanced solutions in non-TBI ICU patients.