SEDCOM
Dexmedetomidine versus Midazolam for Sedation
Paciente / Población Intervención / Exposición Comparación Desenlace
In 375 mechanically ventilated ICU patients, dexmedetomidine reduced delirium compared with midazolam.
N
375
Diseño
Multicentre double-blind RCT
Desenlace
Percentage of time within target RASS sedation range
Relevancia
3
ResultadoNo difference in time at target sedation (77.3% vs 75.1%, P=.18); delirium 54% vs 76.6% (P<.001); extubation 1.9 d earlier (P=.01).
Riker RR, et al. JAMA. 2009;301(5):489-499. 10.1001/jama.2009.56
Discusión y crítica
Established dexmedetomidine as a delirium-sparing alternative to benzodiazepines.