SEDCOM
Dexmedetomidine versus Midazolam for Sedation
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 375 mechanically ventilated ICU patients, dexmedetomidine reduced delirium compared with midazolam.
N
375
Design
Multicentre double-blind RCT
Endpunkt
Percentage of time within target RASS sedation range
Relevanz
3
ErgebnisNo difference in time at target sedation (77.3% vs 75.1%, P=.18); delirium 54% vs 76.6% (P<.001); extubation 1.9 d earlier (P=.01).
Riker RR, et al. JAMA. 2009;301(5):489-499. 10.1001/jama.2009.56
Diskussion & Kritik
Established dexmedetomidine as a delirium-sparing alternative to benzodiazepines.