ROSE
Re-evaluation of Systemic Early Neuromuscular Blockade
Paciente / Población Intervención / Exposición Comparación Desenlace
In 1,006 patients with moderate–severe ARDS on high PEEP, early cisatracurium did not reduce 90-day mortality versus light sedation.
N
1006
Diseño
Multicentre RCT, PETAL Network; stopped early for futility
Desenlace
90-day in-hospital mortality
Relevancia
2
Resultado42.5% vs 42.8% (Δ −0.3%; p=0.93).
PETAL Clinical Trials Network. N Engl J Med. 2019;380(21):1997-2008. 10.1056/NEJMoa1901686
Discusión y crítica
Reserve NMB for refractory dyssynchrony; routine paralysis is no longer indicated.