RECOVERY-RS

Respiratory Strategies in COVID-19

Patient / Population Intervention / Exposure Comparison Outcome

In 1,273 patients with COVID-19 acute hypoxaemic failure, CPAP reduced intubation or death versus conventional oxygen, while HFNO did not.

1,273

Design

Multicentre adaptive RCT, UK

Endpoint

Composite of intubation or 30-day mortality

Relevance

ResultCPAP 36.3% vs O₂ 44.4% (p=0.03); HFNO no benefit.

Perkins GD, et al. JAMA. 2022;327(6):546-558. 10.1001/jama.2022.0028

Discussion & critique

CPAP became standard for COVID-19 hypoxaemia; the HFNO null is partly explained by crossover.