Repici CADe
Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 685 adults undergoing screening, surveillance or diagnostic colonoscopy at three Italian centres, real-time computer-aided detection (GI Genius) increased the adenoma detection rate compared with high-definition colonoscopy without CADe.
N
685
Disegno
Multicentre RCT, Italy
Esito
Adenoma detection rate (ADR)
Rilevanza
1
RisultatoADR 54.8% vs 40.4% (RR 1.30, 95% CI 1.14–1.45); adenomas per colonoscopy 1.07 vs 0.71 (IRR 1.46, 95% CI 1.15–1.86). No difference in withdrawal time (417 vs 435 s; P=0.1) or non-neoplastic resections (26.0% vs 28.7%; RR 1.00, 95% CI 0.90–1.12).
Repici A, et al. Gastroenterology. 2020;159(2):512-520.e7. 10.1053/j.gastro.2020.04.062
Discussione e critica
The multicentre trial that made CADe credible: a large ADR gain without longer withdrawal or more unnecessary resections, and the reference result for the GI Genius device. Three centres, a mandated 6-minute minimum withdrawal and a short recruitment window; transfer to routine practice was tested later (Thiruvengadam, COLO-DETECT) and the step to advanced neoplasia was not found (Mangas-Sanjuan).