Reboli (anidulafungin)
Anidulafungin versus Fluconazole for Invasive Candidiasis
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 245 patients with invasive candidiasis, anidulafungin was superior to fluconazole for global response at end of intravenous therapy.
N
245
Disegno
Double-blind RCT
Esito
Global response at end of intravenous therapy
Rilevanza
2
RisultatoGlobal response 75.6 % vs 60.2 % — superiority of the echinocandin.
Reboli AC, et al. N Engl J Med. 2007;356(24):2472-2482. 10.1056/NEJMoa066906
Discussione e critica
Established echinocandins as first-line therapy for candidaemia — step-down to fluconazole only in stable patients with susceptible isolates.