PROSEVA
Prone Positioning in Severe ARDS
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 466 patients with severe ARDS (P/F <150), early prone positioning ≥16 h/day reduced 28-day mortality compared with supine ventilation.
N
466
Disegno
Multicentre RCT, France
Esito
28-day all-cause mortality
Rilevanza
1
Risultato16.0% vs 32.8% (HR 0.39; 95% CI 0.25–0.63). 90-d mortality 23.6% vs 41.0%.
Guérin C, et al. N Engl J Med. 2013;368(23):2159-2168. 10.1056/NEJMoa1214103
Discussione e critica
Strongest mortality signal in ARDS after ARMA; success required experienced proning teams.