OSCILLATE
High-Frequency Oscillatory Ventilation in Early ARDS
Patient / Population Intervention / Exposure Comparison Outcome
In 548 patients with moderate–severe ARDS, high-frequency oscillatory ventilation increased in-hospital mortality compared with low-tidal-volume ventilation.
N
548
Design
Multicentre RCT, stopped early for harm
Endpoint
In-hospital mortality
Relevance
2
Result47% vs 35%.
Ferguson ND, et al. N Engl J Med. 2013;368(9):795-805. 10.1056/NEJMoa1215554
Discussion & critique
Stopped HFOV as a routine rescue; OSCAR confirmed neutrality.