PROPPR
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 680 patients with severe trauma haemorrhage, a 1:1:1 plasma:platelet:RBC ratio did not change 24-hour or 30-day mortality versus 1:1:2, but reduced death from exsanguination at 24 hours.
N
680
Disegno
Multicentre RCT, USA/Canada
Esito
24-hour and 30-day all-cause mortality
Rilevanza
2
RisultatoNo mortality difference; less death from exsanguination at 24 h with 1:1:1.
Holcomb JB, et al. JAMA. 2015;313(5):471-482. 10.1001/jama.2015.12
Discussione e critica
Best evidence for balanced-ratio massive-transfusion protocols.