PROPPR
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Patient / Population Intervention / Exposure Comparison Outcome
In 680 patients with severe trauma haemorrhage, a 1:1:1 plasma:platelet:RBC ratio did not change 24-hour or 30-day mortality versus 1:1:2, but reduced death from exsanguination at 24 hours.
N
680
Design
Multicentre RCT, USA/Canada
Endpoint
24-hour and 30-day all-cause mortality
Relevance
2
ResultNo mortality difference; less death from exsanguination at 24 h with 1:1:1.
Holcomb JB, et al. JAMA. 2015;313(5):471-482. 10.1001/jama.2015.12
Discussion & critique
Best evidence for balanced-ratio massive-transfusion protocols.