PREVENT
MBCT-Taper vs Maintenance Antidepressant
Doente / População Intervenção / Exposição Comparação Desfecho
In 424 adults in remission from recurrent depression, MBCT with antidepressant taper achieved the same 24-month relapse as maintenance antidepressant therapy.
N
424
Desenho
Multicentre RCT, UK
Desfecho
Time to depressive relapse over 24 months
Relevância
2
ResultadoRelapse 44% (MBCT) vs 47% (ADM); non-inferior. HR 0.89 (95% CI 0.67–1.18).
Kuyken W, et al. Lancet. 2015;386(9988):63-73. 10.1016/S0140-6736(14)62222-4
Discussão e crítica
Positions MBCT as a credible alternative for patients who want to come off antidepressants.