PREVENT
MBCT-Taper vs Maintenance Antidepressant
Patient / Population Intervention / Exposure Comparison Outcome
In 424 adults in remission from recurrent depression, MBCT with antidepressant taper achieved the same 24-month relapse as maintenance antidepressant therapy.
N
424
Design
Multicentre RCT, UK
Endpoint
Time to depressive relapse over 24 months
Relevance
2
ResultRelapse 44% (MBCT) vs 47% (ADM); non-inferior. HR 0.89 (95% CI 0.67–1.18).
Kuyken W, et al. Lancet. 2015;386(9988):63-73. 10.1016/S0140-6736(14)62222-4
Discussion & critique
Positions MBCT as a credible alternative for patients who want to come off antidepressants.