PRESERVE
Prevention of Serious Adverse Events Following Angiography
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 5,177 high-risk patients undergoing angiography, intravenous sodium bicarbonate or acetylcysteine did not reduce contrast-associated kidney outcomes compared with control.
N
5177
Disegno
2×2 factorial RCT, stopped for futility
Esito
Composite of death, dialysis or persistent creatinine rise at 90 days
Rilevanza
2
RisultatoBicarbonate OR 0.93 (p=0.62); acetylcysteine OR 1.02 (p=0.88).
Weisbord SD, et al. N Engl J Med. 2018;378(7):603-614. 10.1056/NEJMoa1710933
Discussione e critica
Retired routine bicarbonate and acetylcysteine; isotonic saline volume expansion remains the only prophylaxis.