PRAGUE-OHCA
Effect of Intra-arrest Transport, Extracorporeal CPR, and Immediate Invasive Assessment in Refractory OHCA
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 256 patients with refractory out-of-hospital cardiac arrest, a hyperinvasive strategy (intra-arrest transport + ECPR + immediate cath) did not significantly improve 180-day CPC 1–2 survival versus standard ACLS.
N
256
Schéma
Single-centre RCT, Prague; stopped for futility
Critère
Survival with CPC 1–2 at 180 days
Pertinence
3
Résultat31.5% vs 22.0% (OR 1.63; 95% CI 0.93–2.85; p=0.09). 30-day CPC 1–2 30.6% vs 18.2% (p=0.02).
Belohlavek J, et al. JAMA. 2022;327(8):737-747. 10.1001/jama.2022.1025
Discussion et critique
Single-centre signal of benefit without meeting the primary endpoint; argues for selective ECPR networks.