Ponticelli
Ponticelli Regimen for Idiopathic Membranous Nephropathy
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 62 patients with idiopathic membranous nephropathy, alternating monthly methylprednisolone and a cytotoxic agent increased remission of nephrotic syndrome compared with supportive care.
N
62
Disegno
RCT, mean 31-month follow-up
Esito
Complete or partial remission of nephrotic syndrome
Rilevanza
3
Risultato23/32 (72%) treated versus 9/30 (30%) controls in remission (p=0.001).
Ponticelli C, et al. N Engl J Med. 1984;310(15):946-950. 10.1056/NEJM198404123101503
Discussione e critica
A decades-long first-line cytotoxic regimen for progressive membranous nephropathy; its toxicity drove the search for rituximab alternatives.