Ponticelli
Ponticelli Regimen for Idiopathic Membranous Nephropathy
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 62 patients with idiopathic membranous nephropathy, alternating monthly methylprednisolone and a cytotoxic agent increased remission of nephrotic syndrome compared with supportive care.
N
62
Design
RCT, mean 31-month follow-up
Endpunkt
Complete or partial remission of nephrotic syndrome
Relevanz
3
Ergebnis23/32 (72%) treated versus 9/30 (30%) controls in remission (p=0.001).
Ponticelli C, et al. N Engl J Med. 1984;310(15):946-950. 10.1056/NEJM198404123101503
Diskussion & Kritik
A decades-long first-line cytotoxic regimen for progressive membranous nephropathy; its toxicity drove the search for rituximab alternatives.