POET
Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 400 patients with stable left-sided endocarditis after ≥10 days of IV therapy, step-down to oral two-drug therapy was non-inferior to continued IV therapy for a composite of mortality, embolic events, relapse or unplanned cardiac surgery.
N
400
Design
Open-label non-inferiority RCT
Endpunkt
Composite at 6 months
Relevanz
2
Ergebnis12.1 % (IV) vs 9.0 % (oral) — non-inferior; durability confirmed at 5 yr.
Iversen K, et al. N Engl J Med. 2019;380(5):415-424. 10.1056/NEJMoa1808312
Diskussion & Kritik
Paradigm shift: in carefully selected, clinically stable left-sided endocarditis, completion of therapy can be oral — incorporated into ESC 2023 and AHA endocarditis guidance.