PEXIVAS
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
Paciente / Población Intervención / Exposición Comparación Desenlace
In 704 patients with severe ANCA-associated vasculitis, plasma exchange did not reduce death or end-stage kidney disease compared with no plasma exchange.
N
704
Diseño
2×2 factorial RCT
Desenlace
Composite of death or end-stage kidney disease
Relevancia
1
ResultadoPlasma exchange HR 0.86 (95% CI 0.65–1.13); reduced-dose steroids non-inferior with fewer serious infections.
Walsh M, et al. N Engl J Med. 2020;382(7):622-631. 10.1056/NEJMoa1803537
Discusión y crítica
Ended routine plasma exchange in ANCA vasculitis and made reduced-dose steroid schedules standard.