PARTNER 3
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,000 patients with severe AS at low surgical risk, TAVR with the SAPIEN 3 valve reduced death, stroke or rehospitalisation at one year versus surgical AVR.
N
1.000
Design
RCT, 1 yr (non-inferiority + superiority)
Endpunkt
Death, stroke, rehospitalisation
Relevanz
1
Ergebnis8.5 % vs 15.1 % (HR 0.54).
Mack MJ, et al. N Engl J Med. 2019;380(18):1695-1705. 10.1056/NEJMoa1814052
Diskussion & Kritik
Driven largely by rehospitalisation. Longer-term durability data still maturing — relevant for younger, low-risk patients with decades of remaining life.