PARTNER 1B

Placement of Aortic Transcatheter Valves — cohort B (inoperable)

Patient / Population Intervention / Exposure Comparison Outcome

In 358 patients with severe AS deemed inoperable, transcatheter aortic-valve replacement reduced all-cause mortality at 1 year compared with medical therapy.

358

Design

RCT, 1 yr

Endpoint

All-cause mortality

Relevance

Result30.7 % vs 50.7 % (HR 0.55).

Leon MB, et al. N Engl J Med. 2010;363(17):1597-1607. 10.1056/NEJMoa1008232

Discussion & critique

Vascular complications and stroke rates high in early TAVR — improved markedly in subsequent generations. Established TAVR for inoperable patients.