NINDS rt-PA
Tissue Plasminogen Activator for Acute Ischemic Stroke
Paciente / Población Intervención / Exposición Comparación Desenlace
In 624 patients with acute ischaemic stroke within 3 h, intravenous alteplase 0.9 mg/kg improved functional outcome at 3 months versus placebo.
N
624
Diseño
Double-blind RCT, NIH
Desenlace
Favourable functional outcome at 90 days
Relevancia
1
ResultadoPart 2 OR 1.7 (95% CI 1.2–2.6; p=0.008). Symptomatic ICH 6.4% vs 0.6%.
The NINDS rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581-1587. 10.1056/NEJM199512143332401
Discusión y crítica
Founding trial of IV thrombolysis; ICH risk shaped patient selection and quality metrics for two decades.