NICE-SUGAR

Intensive versus Conventional Glucose Control in Critically Ill Patients

Patient / Population Intervention / Exposure Comparison Outcome

In 6,104 ICU patients, intensive glucose control (81–108 mg/dL) increased 90-day mortality versus conventional (<180 mg/dL), with much more severe hypoglycaemia.

6,104

Design

International RCT

Endpoint

90-day all-cause mortality

Relevance

Result27.5% vs 24.9% (OR 1.14; p=0.02). Severe hypoglycaemia 6.8% vs 0.5%.

NICE-SUGAR Study Investigators. N Engl J Med. 2009;360(13):1283-1297. 10.1056/NEJMoa0810625

Discussion & critique

Buried tight glucose control; modern targets are <180 mg/dL (Surviving Sepsis 144–180).