MR CLEAN
Endovascular Treatment for Acute Ischemic Stroke
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 500 patients with proximal anterior-circulation occlusion within 6 h, intra-arterial thrombectomy + standard care improved the 90-day mRS distribution versus standard care alone.
N
500
Disegno
Multicentre RCT, Netherlands
Esito
mRS shift at 90 days
Rilevanza
1
RisultatoAdj. common OR 1.67 (95% CI 1.21–2.30). mRS 0–2: 32.6% vs 19.1%.
Berkhemer OA, et al. N Engl J Med. 2015;372(1):11-20. 10.1056/NEJMoa1411587
Discussione e critica
Inflection point — together with ESCAPE/EXTEND-IA/SWIFT PRIME/REVASCAT (HERMES) made mechanical thrombectomy standard within 6 h.