MITRA-FR
Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 304 patients with heart failure and severe secondary mitral regurgitation, transcatheter mitral repair did not reduce death or heart-failure hospitalisation compared with medical therapy alone.
N
304
Disegno
Open-label RCT, 1 yr
Esito
Death or HF hospitalisation at 12 months
Rilevanza
2
Risultato54.6 % vs 51.3 % (OR 1.16, 95% CI 0.73–1.84; P=0.53).
Obadia JF, et al. N Engl J Med. 2018;379(24):2297-2306. 10.1056/NEJMoa1805374
Discussione e critica
Negative where COAPT was positive — explained by patient selection: 'proportionate' MR with larger ventricles. The EROA/LVEDV ratio helps identify who benefits from repair.