MIND-USA
Modifying the Impact of ICU-Associated Neurological Dysfunction
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 566 ICU patients with delirium, haloperidol or ziprasidone did not change delirium duration versus placebo.
N
566
Schéma
Multicentre RCT, USA
Critère
Days alive without delirium or coma
Pertinence
2
RésultatMedian days alive without delirium/coma: 8.5 (placebo) vs 7.9 (haloperidol) vs 8.7 (ziprasidone); P=0.26 overall. No difference.
Girard TD, et al. N Engl J Med. 2018;379(26):2506-2516. 10.1056/NEJMoa1808217
Discussion et critique
Killed routine antipsychotic prophylaxis/treatment for ICU delirium.