MADIT-CRT
Multicenter Automatic Defibrillator Implantation Trial with CRT
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,820 patients with mild heart failure (NYHA I–II) and a wide QRS, adding resynchronisation to a defibrillator reduced death or heart-failure events compared with a defibrillator alone.
N
1.820
Design
RCT
Endpunkt
Death or non-fatal heart-failure event
Relevanz
2
ErgebnisHR 0.66; benefit confined to left bundle-branch block.
Moss AJ, et al. N Engl J Med. 2009;361(14):1329-1338. 10.1056/NEJMoa0906431
Diskussion & Kritik
Extended CRT to mild HF, but only LBBB morphology benefits — non-LBBB QRS widening should not be resynchronised.