Leuven I
Intensive Insulin Therapy in Critically Ill Surgical Patients
Doente / População Intervenção / Exposição Comparação Desfecho
In 1,548 surgical ICU patients, intensive insulin (80–110 mg/dL) reduced ICU mortality versus conventional control.
N
1548
Desenho
Single-centre RCT, Belgium
Desfecho
ICU mortality
Relevância
3
Resultado4.6% vs 8.0% (p<0.04).
Van den Berghe G, et al. N Engl J Med. 2001;345(19):1359-1367. 10.1056/NEJMoa011300
Discussão e crítica
Single-centre, mostly cardiac surgery; NICE-SUGAR later overturned tight control in general ICU.